Research on Devices for Handling Whole Slide Images on Pathology Workstations. An Ergonomic Outlook

Background Digital Pathology represents a technological innovation that introduces changes in the traditional tasks of pathologists. In this regard, an important issue that has not been enough emphasized is the image handling from an ergonomic point of view to avoid work-related musculoskeletal disorders (MSD). The aim of this study was to investigate a proper input device for digital pathology. Material & Methods Research was conducted in two phases: (1). A comparative study to find out an optimal external controller. Eight medical students analyzed 11 input devices: keyboard (Hewlett Packard, HP), conventional mouse (HP), vertical mouse (CLS), touchpad (Logitech), 3 trackballs (Logitech, Kensington Expert and Ulove), Rollermouse (Contour), Ergopointer (Märzhäuser Sensotech), gamepad (Logitech) and a touchless device (Leap Motion Controller), using them with the Image Viewer software (Ventana). The web-based Fitts´ law test (UC Berkeley) was used to objectify the accuracy of each used device, randomly. 12 items were included in the questionnaire: comfort, technical aspects (cursor movement and objective achievement), prospects, overall satisfaction, prior experience, and others. (2). Evaluation by two experienced pathologists of the best rated input device on the previous experiment and its comparison with a voice recognition system (Invox Medical Dictation, Vocali) using a headset microphone (Plantronics). Perceived workload was scored using the NASA Task Load Index on 28 whole slide images visualized on the Digital Image Hub (Leica) platform with a 4 MegaPixel display (Barco). Data were processed with SPSS 21.0. Results Correlation between technical aspects of the evaluated devices and accuracy (Fitts´ law test), and comfort with overall satisfaction, was demonstrated (p<0.05). Comparative analysis of the 11 input devices concluded that vertical mouse was the best rated input device. However, on the second phase of the study, we find a slightly higher perceived workload using this device than using the voice recognition system, which was the best controller in digital pathology from an ergonomic point of view in this study. Conclusions We describe a methodology that can study and compare input devices for future workstations in digital pathology. Pathologists should be involved in this process trying to find ergonomic devices that prevent MSD. Voice recognition can function as a good handsfree device for digital pathology and could be considered in physical disability situations. Further studies using electromyography, accelerometry and 3D reconstruction analysis could provide additional ergonomic information

“Viceversos SocioArquitectónicos”: líneas de transversalidad entre Sociología, Geografía y Arquitectura

Introduciendo en los espacios de discusión al Departamento de Geografía Humana, el objetivo de la Red para retro-alimentar prácticas docentes mediante la aplicación de metodologías aparentemente exclusivas se mantiene, como también que dichas metodologías compartidas se aplican en acciones participadas por estudiantes y que acaban constituyendo prácticas para ser presentadas como TFGs o PFCs. El balance en cuanto a materiales producidos cuya visibilidad es ahora pública es: una comunicación presentada y leída; otra comunicación presentada y prevista su lectura en Noviembre; dos resúmenes presentados, una comunicación y organización de la Jornada “Competencias Cívicas”; y el inicio de otros campos de trabajo que se apuntan para el curso próximo. El último formato de debate y expositivo tuvo lugar fuera de la Universidad, con una jornada de investigación abierta al público y que actuó como motor de iniciativas de contenidos o metodologías sobre desarrollo local, técnicas de diseño compartido, patrimonio, medición de impactos en proyectos, fabricación digital y virtualización

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients

Hepsin is a type II transmembrane serine protease whose deregulation promotes tumor invasion by proteolysis of the pericellular components. In colorectal cancer, the implication of hepsin is unknown. Consequently, we aimed to study the correlations between hepsin expression and different clinical-histopathological variables in 169 patients with localized colorectal cancer and 118 with metastases. Tissue microarrays were produced from samples at diagnosis of primary tumors and stained with an anti-hepsin antibody. Hepsin expression was correlated with clinical-histopathological variables by using the chi-square and Kruskal&ndash;Wallis tests, Kaplan&ndash;Meier and Aalen&ndash;Johansen estimators, and Cox and Fine and Gray multivariate models. In localized cancer patients, high-intensity hepsin staining was associated with reduced 5-year disease-free survival (p-value = 0.16). Medium and high intensity of hepsin expression versus low expression was associated with an increased risk of metastatic relapse (hazard ratio 2.83, p-value = 0.035 and hazard ratio 3.30, p-value = 0.012, respectively), being a better prognostic factor than classic histological variables. Additionally, in patients with localized tumor, 5-year thrombosis cumulative incidence increased with the increment of hepsin expression (p-value = 0.038). Medium and high intensities of hepsin with respect to low intensity were associated with an increase in thrombotic risk (hazard ratio 7.71, p-value = 0.043 and hazard ratio 9.02, p-value = 0.028, respectively). This relationship was independent of previous tumor relapse (p-value = 0.036). Among metastatic patients, low hepsin expression was associated with a low degree of tumor differentiation (p-value &lt; 0.001) and with major metastatic dissemination (p-value = 0.023). Hepsin is a potential thrombotic and metastatic biomarker in patients with localized colorectal cancer. In metastatic patients, hepsin behaves in a paradoxical way with respect to differentiation and invasion processes

Trastornos del desarrollo con discapacidad motora : proceso asistencial integrado

Publicado en la página web de la Consejería de Igualdad, Salud y Políticas Sociales: www.juntadeandalucia.es/salud (Consejería de Salud / Profesionales / Nuestro Compromiso por la Calidad / Procesos Asistenciales Integrados)YesConjunto de actuaciones coordinadas por el Sistema Sanitario Público de Andalucía desarrolladas por profesionales de distintos sectores que atienden a la población infantil, familiares y entorno, cuya finalidad es la prevención, diagnóstico, tratamiento y seguimiento de los trastornos del desarrollo que afectan predominantemente al área motor de niños y niñas de 0 a 6 años. Este subproceso está dedicado a aquellos niños y niñas con Trastornos Generalizados y Focales que afectan al desarrollo motor y no exclusivamente a aquellos afectos de Parálisis Cerebral

“Viceversos SocioArquitectónicos”: líneas de transversalidad entre Sociología, Geografía y Arquitectura

Introduciendo en los espacios de discusión al Departamento de Geografía Humana, el objetivo de la Red para retro-alimentar prácticas docentes mediante la aplicación de metodologías aparentemente exclusivas se mantiene, como también que dichas metodologías compartidas se aplican en acciones participadas por estudiantes y que acaban constituyendo prácticas para ser presentadas como TFGs o PFCs. El balance en cuanto a materiales producidos cuya visibilidad es ahora pública es: una comunicación presentada y leída; otra comunicación presentada y prevista su lectura en Noviembre; dos resúmenes presentados, una comunicación y organización de la Jornada “Competencias Cívicas”; y el inicio de otros campos de trabajo que se apuntan para el curso próximo. El último formato de debate y expositivo tuvo lugar fuera de la Universidad, con una jornada de investigación abierta al público y que actuó como motor de iniciativas de contenidos o metodologías sobre desarrollo local, técnicas de diseño compartido, patrimonio, medición de impactos en proyectos, fabricación digital y virtualización

Image et transmission des savoirs dans les mondes hispaniques et hispano-américains

C'est devenu une banalité que de dire que l'image est aujourd'hui partout autour de nous. Cette présence quotidienne, voire envahissante à certains égards, de l'image fait que l'on peut même parler au XXe siècle d'une "civilisation de l'image". Les progrès de l'instruction, le développement de la presse et de l'imprimerie, l'apparition de techniques nouvelles (la photographie, puis le cinéma), ont conduit en effet à donner à l'image une importance inconnue jusque-là. Mais l'image a traditionnellement servi d'instrument privilégié de communication, de support didactique, par sa charge émotionnelle et symbolique. Ce volume permet d'approcher à partir de cas et de situations concretes, dans les mondes hispaniques et hispano-américains, l'évolution historique et contextualisée de la transmission des savoirs via l'image ainsi que la nature et les spécificités des documents iconographiques permettant cette approche. Les cinquante quatre interventions rassemblées dans ce volume ont été regroupées dans quatre rubriques, respectivement intitulées "Représentations et lieux de mémoire", "Du manuscrit au livre. Symboliques et emblématiques", "L'imagerie scolaire" et "Medias. Presse, publicité, cinéma". Les supports utilisés par les auteurs de toutes ces contributions sont extrêmement variés, et vont du dessin ou de la gravure et de la peinture (y compris les peintures murales) à la sculpture, à la photographie (y compris sous forme de diapositives) et au cinéma, sans oublier le théâtre et, sans doute plus original, la monnaie. Le manuscrit, le livre et la presse constituent bien entendu autant d'éléments sur lesquels porte l'analyse iconographique